CET Cancer Center, High Dose Rate (hdr) Brachytherapy Specialist with 25 years of experience
310-206-2510
Contact Us
As of January 4, 2010 Dr. Demanes and the program have relocated to UCLA.

High Dose Rate Brachytherapy Publications


Prostate Publications and Articles

  1. High-dose-rate intensity modulated brachytherapy with External Beam Irradiation for Prostate Cancer: California endocurietherapy's 10-year results
  2. Lack of Benefit from A Short Course of Androgen Deprivation for Unfavorable Prostate Cancer Patients Treated with an Accelerated Hypofractionated Regime
  3. High Dose Rate Monotherapy for Prostate Cancer Early Result
  4. Lack of Benefit of Pelvic Radiation in Prostate Cancer Patients with a High Risk of Positive Pelvic Lymph Nodes Treated with High-Dose Radiation
  5. High Dose Rate Monotherapy for Prostate Cancer: CET's 5-year results
  6. Long Term Results of HDR Brachytherapy and external Beam with and without short term androgen suppression for prostate cancer
  7. High dose rate prostate brachytherapy: the California Endocurietherapy (CET) Method
  8. How to compare published prostate study results

Breast Publications

  1. The use of high-dose-rate brachytherapy alone after lumpectomy in patients with early-stage breast cancer treated with breast-conserving therapy
  2. Accelerated partial breast irradiation using MammoSite brachytherapy: a multidisciplinary approach to breast-conservation therapy
  3. Initial clinical experience with the MammoSite breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy

Gynecologic Publications

  1. The American Brahytherapy Society Recommendations for High-Dose-Rate Brachytherapy for Carcinoma of The Cervix
  2. High Dose Rate Transperineal Interstitial Brachytherapy for Cervical Cancer: High Pelvic Control and Low Complication Rates
  3. The Use and Advantages of a Multichannel Vaginal Cylinder in High Dose Rate Brachytherapy
  4. Low Dose Rate Brachytherapy in Vaginal Carcinoma: Long Term Outcome and Morbidity

Head and Neck Publications

  1. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for head-and-neck carcinoma
  2. Wire in Leader Technique: A method for loading implant catheters in inaccessible sites

Home

Treatment Programs


Printable Material


Treatments Statistics


Glossary


Frequently Ask Questions


General Information


Brachytherapy Publications


Cancer Resources & Links




Back to TopGeneral Frequently Asked Questions


1. What is Brachytherapy?


The prefix "brachy" is the Greek word for "short" distance. Brachytherapy is a form of internal radiation treatment where radioactive sources are placed on or into cancer tissues. There are two kinds of brachytherapy. The radiation sources may be inserted either permanently or temporarily. The two most common forms of treatment are low dose rate (LDR) permanent seeds for prostate cancer and high dose rate (HDR) temporary brachytherapy, that can be used for prostate, gynecologic, breast, head and neck, lung, esophageal, bile duct, anorectal, sarcoma, and other cancers.

2. What is high dose rate (HDR) Brachytherapy?


High dose rate (HDR) is a technically advanced form of brachytherapy. A high intensity radiation source is delivered with millimeter precision under computer guidance directly into the tumor killing it from the inside out while avoiding injury to surrounding normal healthy tissue. For a more in depth explanation please visit the understanding HDR Brachytherapy page.

3. How does radiation kill cancer?


Cancer is made of abnormal cells that tend to grow without control. Cancer DNA is more sensitive to radiation than are normal cells, so radiation kills cancer directly or when the cells attempt to multiply while normal tissue in the region is able to repair and recover.


4. What are the advantages of HDR Brachytherapy?

  • Short course of treatment compared to other types of radiation treatment (1 week)
  • Preservation of organ structure and function
  • Fewer side effects
  • Excellent coverage of possible microscopic extension of cancer
  • Knowledge of radiation dose distribution before treatment is given
  • Accuracy and precision of tumor specific radiation dose delivery
  • Minimizes areas of radiation overdose (hot spots) or underdose (cold spots)
  • Organ motion (target movement) is not a problem for HDR as it is with external beam
Prostate Specific
Breast Specific
  • Conserves the breast and yields excellent cosmetic results
  • Reduces radiation dose to the heart, lungs, and opposite breast
  • Doesn't cause a delay in other treatments such as chemotherapy

For more information on the advantages for specific cancer sites please click on the appropriate link below:
Prostate cancer | Breast Cancer | Gynecologic Cancer | Head & Neck Cancer
Esophageal and Bile Duct Cancer | Lung Cancer | Soft Tissue Sarcoma Cancer

5. How successful is HDR Brachytherapy?


HDR Brachytherapy is effective treatment of local disease in many forms of cancer including prostate, gynecological, breast, head and neck, esophagus, lung, anorectal, bile duct, sarcoma, and other primary cancer or localized metastasis as reported in medical literature. CET's publication on prostate cancer, for example has demonstrated 90% 10-year tumor control. Success rates for other tumors vary according to the type and stage of cancer being treated.

6. How many treatments has CET administered?


As of 7/31/2009, CET has performed 10,090 HDR implants and delivered 21,428 HDR treatments. Please see our treatment statistics for further details.

7. Why is HDR less well known than other forms of cancer treatment?


HDR Brachytherapy is a relatively new form of advance radiation technology. Fewer physicians have been trained to perform HDR procedures compared to seed implants or external beam radiation. Few centers, other than CET have been dedicated to the development of HDR brachytherapy to its full potential. Dr. Demanes has devoted his career to the advancement of brachytherapy and has pioneered the use of HDR and established CET as a center of excellence with specially trained and experienced staff and physicians.

8. Why should I select CET?

Please see CET Advantage for more information.


Back to TopAbout Us

Membership and affiliations
American Society for Therapeutic Radiology And Oncology
Chair - Health Policy and Economics Practice Management Subcommittee,
Chair - Regulatory Subcommittee, Member - Health Policy and Economic Committee,
Member - Health Policy and Economics Code Development and Valuation Subcommittee,
Member - Code Utilization and Application Subcommittee.
American Brachytherapy Society
Chair - Socioeconomic Committee.
American College of Radiation Oncology
President - 2005 to 2007
American College of Radiology
Fellow - 2007